Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances
/ResearchGate/2026
Why It Matters
This paper caught my attention because BPC-157 gets promoted online as a healing peptide, but most discussions focus on tissue repair. This study suggests it might also affect dopamine pathways and addiction-related behaviors. That said, this is rat data showing it can modify drug-induced behavior changes — we're miles away from knowing if it does anything similar in humans dealing with stimulant use or dopamine dysregulation.
Key Findings
- BPC-157 reduced stereotyped behaviors (repetitive movements) caused by chronic amphetamine administration in rats across a wide dose range (10 ng/kg to 10 μg/kg)
- The peptide attenuated locomotor sensitization — the progressive increase in movement response that develops with repeated amphetamine exposure
- Effects occurred with both intraperitoneal injection and drinking water administration, suggesting oral bioavailability in rats
- The dose-response curve was unusual — effects seen at extremely low doses (nanogram range) and higher doses (microgram range), suggesting multiple mechanisms of action
- Study focused on behavioral outcomes only — no mechanism data, receptor binding, or neurochemical measurements were reported