Hepatoprotective effect of BPC 157
Sikiric et al./PubMed/1993
Why It Matters
This paper caught my attention because BPC-157 has become popular in biohacking circles, but most people don't realize the evidence is almost entirely in rodents. This 1993 study shows protective effects on rat livers under extreme injury conditions, which is interesting mechanistically but tells us nothing about whether it helps human liver health or has acceptable safety in people. Not a doctor. Just a guy who reads the papers — and this one is purely preclinical.
Key Findings
- BPC-157 prevented liver necrosis and fatty changes in rats with 24-hour bile duct and hepatic artery ligation, a severe injury model
- The peptide protected against liver damage from 48 hours of restraint stress in rats
- BPC-157 prevented liver injury from carbon tetrachloride administration (1 ml/kg), a toxic chemical used to model liver damage
- Standard reference drugs (bromocriptine, amantadine, somatostatin) provided little or no protection in these models
- Blood markers (bilirubin, SGOT, SGPT) correlated with the visible liver damage, suggesting BPC-157 affected actual liver health not just lab values
Read the Paper↗PMID: 7901724