The Inflammation Cluster
6 genetic variants creating a pro-inflammatory profile
The 30-Second Version
Duration: 40 seconds Compliance: Can say gene names (TNF-alpha, etc.), "inflammation," "CRP." Don't name specific compounds used for treatment.
"I ate clean. I exercised. I slept well.
My inflammation was still through the roof.
Turns out I have six genetic variants - three that crank inflammation UP, and three that should pull it DOWN but don't work properly.
Hit from both sides. Lifestyle alone was never going to fix it.
Once my medical team and I knew which specific pathways were overactive, we could target them. Not just 'eat more turmeric.' Actually target the mechanism.
Result: inflammation dropped 71% in three months.
If you're doing everything right and your CRP is still high - your genetics might be the answer nobody's checking.
Link in bio for the full breakdown."
Last line (quotable): "The answer to 'why am I inflamed?' might be in your DNA."
I eat clean. I exercise. I sleep 7-8 hours.
My inflammation marker (hs-CRP) was still 3.5 mg/L. That's cardiac risk territory.
Then I found 6 genetic variants that explained everything. 🧵
Your body has genes that DRIVE inflammation and genes that BRAKE it. I got unlucky on both sides.
Drivers (all high-activity):
- TNF-alpha: GG
- IL-1beta: GG
- IL-6: GG
Brakes (all impaired):
- IL-10: TT (anti-inflammatory - reduced)
- CRP: CC (genetically higher baseline)
- IL2RA: TT (immune regulation - impaired)
Three genes pushing inflammation UP. Three genes that should pull it DOWN - broken.
This is genetic. Eating broccoli wasn't going to fix it.
I needed a targeted protocol based on these specific pathways, designed with my medical team.
What actually moved the needle:
- Targeted the NF-kB pathway (the master inflammation switch)
- High-dose omega-3 (my FADS genes show I can't convert plant omega-3s, need preformed EPA/DHA)
- Lost 50 lbs (adipose tissue is an inflammation factory)
- Specific compounds targeting TNF-alpha and IL-6
Results:
hs-CRP: 3.5 → 1.0 mg/L
71% reduction.
Not from a generic "anti-inflammatory diet." From knowing WHICH inflammatory pathways were genetically overactive and targeting them specifically.
If your CRP is elevated and you're doing "everything right" - your genetics might be the missing variable.
Standard bloodwork won't show this. You need genetic testing that covers inflammatory cytokine SNPs.
The answer to "why am I inflamed?" might be in your DNA.
This is what I put in The Manual every week.
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